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A narrative review concluded that the practice is controversial because there are no standardized dosing protocols and nearly onethird of patients report adverse effects, ranging from mild gastrointestinal symptoms to liver dysfunction and lifethreatening allergic reactions

In women with PCOS who have vitamin D deficiencies, co-supplementation of calcium and vitamin D has demonstrated improvements in -cell function, TAC, high-sensitivity C-reactive protein (hs-CRP), and glutathione (GSH) levels [142]

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Amino acid losses during hemodialysis with polyacrylonitrile membranes: effect of intradialytic amino acid supplementation on plasma amino acid concentrations and nutritional variables in nondiabetic patients